Aptamer-patterned hydrogel films for spatiotemporally programmable capture and release of multiple proteins
作者：Zheng Zhang, Chen Liu, Chunzheng Yang, Yuyang Wu, Feng Yu, Yong Chen, Jie Du*
關(guān)鍵字：aptamer-patterned hydrogel, controlable release
論文來源：期刊
具體來源：ACS Applied Materials & Interfaces
發(fā)表時(shí)間：2018年
Various hydrogels have been used for protein delivery in the treatment of human diseases. Nevertheless, it is always difficult to control the capture and release of multiple proteins in different regions and periods. This research successfully proves that multiple proteins can be captured and released from the aptamer-patterned hydrogelfilms with an adjustable release rate at a prospective time and in specific regions utilizing the complementary DNA strand of aptamers via photoclick chemistry and DNA hybridization. The hydrogel film is successfully applied to complex matrixes such as human serum and has excellent cytocompatibility.
Thus, the aptamer-patterned hydrogelfilm will be a good candidate for controlled delivery of multiple proteins.