10. Evaluation of pH-Sensitive Poly(b-amino ester)-graft-poly(ethylene glycol) and its Usefulness as a pH-Sensor and Protein Carrier
writer：Min Sang Kim, Guang Hui Gao, Seong Woo Kang, Doo Sung Lee
keywords：Protein delivery
source：期刊
specific source：Macromol. Biosci.
Issue time：2011年
In this study, some possible biomedical applications of a pH-sensitive and amphiphilic
copolymer as a pH sensor and protein delivery system are reported. PAE-g-PEG was used
as a pH-sensitive polymer that can exhibit a sharp pH-dependent transition. Various fluore-
scent dyes including pyrene and RITC can be used to label the pH-sensitive polymer PAE-g-PEG,
which was evaluated for protein encapsulation. pH-sensing was possible by observing
excimer formation of the labeled pyrene via pH-dependent expansion of the polymeric
chain. Also, it was confirmed that FITC-BSA could be entrapped in RITC-labeled pH-sensi-
tive micelles of PAE-g-PEG by FRET. As a result,
PAE-g-PEG can be a pH sensor and carrier for
protein delivery.