Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy
作者：Chao Zhong, Xiufeng Zhang*, Yanfang Sun, Zhong Shen, Yanan Mao, Tianqiu Liu, Rui Wang, Lei Nie, Amin
關(guān)鍵字：Microneedles, migraine, rizatriptan benzoate, transdermal drug delivery
論文來(lái)源：期刊
具體來(lái)源：Journal of Biomaterials Applications
發(fā)表時(shí)間：2024年
Abstract: In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.