【Chinese Journal of Polymer Science，IF=3.603】A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks
作者：Jiang R., Yan S., Tian L., et al.
關(guān)鍵字：Antibacterial surface, Metal-phenolic coating, DNA-cleavage, Biomimetic surface
論文來源：期刊
發(fā)表時(shí)間：2018年
Chinese Journal of Polymer Science 發(fā)表時(shí)間：2018年 Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA (eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes (deoxyribonuclease), here we report a novel antibacterial surface by employing cerium (Ce(IV)) ion to mimic the DNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid (TA) works as an essential scaffold and Ce(IV) ion acts as both a cross-linker and a destructor of eDNA. The Ce(IV)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(III)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.