231. Disulfide-crosslinked Poly(L-glutamic acid) Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery.
作者：H. Y. Wu, J. H. Li, J. C. Wei, Y. F. Dai, Z. P. Peng, Y. W. Chen, T. X. Liu.
關鍵字：PLGA, Mesoporous Silica Nanoparticles, Drug Delivery
論文來源：期刊
具體來源：Chem. Res. Chin. Univ., 2015, 31(5), 890-894.
發(fā)表時間：2015年
Poly(L-glutamic acid)(PLGA) was grafted onto the surface of
mesoporous silica nanoparticles(MSN) via the ring opening
polymerization of γ-benzyl-L-glutamate N-carboxyanhydride(BLG-NCA) and its subsequent deprotection of benzyl
groups. The PLGA chains were cross-linked with cystamine, and thus forming a
type of redox responsive drug delivery system(MSN-cPLGA). The
structures were characterized by Fourier transform infrared spectrometry(FTIR),
transmission electron microscopy(TEM) and energy disperse spectrometry(EDS),
demonstrating that disulfide groups existed on the surfaces of
MSN-cPLGA particles. The thermal gravimetric analysis(TGA) results show
that the PLGA mass fraction is about 33.4% in the MSN-cPLGA hybrid. The in vitro drug release experiments showed that the MSN-cPLGA
hybrid can realize the controlled release of model drugs(5-fluorouracil) in
response to redox environment. Even 0.1 mmol/L dithiothreitol(DTT) can
accelerate the drug release speed, and a concentration of 10.0 mmol/L DTT is
higher enough to trigger the open of cross-linked PLGA network so as to realize
rapid release of drugs. All the results demonstrate that the cross-linked PLGA
chains on the surface of MSN could act as efficient gatekeepers to control the
on-off of the pores, showing potential application in drug delivery system.