【Journal Materials Science & Technology】Electrostatic Assembly Functionalization of Poly(γ-Glutamic Acid) for Biomedical Antibacterial Applications
作者：Xiaodan wang, Hengchong Shi, Haoyu Tang, Xu Zhang, Shifang Luan*，et al.,
關鍵字：Electrostatic assembly, Antibacterial coating
論文來源：期刊
具體來源：Journal Materials Science & Technology
發(fā)表時間：2020年
Abstract:
Poly (γ-glutamic acid) (γ-PGA) has been found widespread applications in biomedical fifield because of its excellent water solubility, biocompatibility, and bioactivity. Herein, a water-insoluble γ-PGA antibac terial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyllauroyl arginate (ELA). The functionalized γ-PGA compound (γ-PGA-ELA) ethanol solution can facilely produce colorless and transparent coatings on various inorganic, metal, and polymeric substrates, espe-cially for the lumen of slender catheters (length up to 2 m, and inner diameter down to 1 mm). The functionalized γ-PGA coating presents remarkable antibacterial effificacy in vitro and in vivo. In addition,the γ-PGA compound is used as antibacterial additives of polyolefifin via melting extrusion, and the as-prepared antibacterial polyolefifin demonstrates advantageous antibacterial effificacy. More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility, low cytotoxicity, and satisfactory histocompatibility. The as-proposed γ-PGA compound has a great potential to serve as a safe and multi-functional antibacterial candidate to combat biomedical devices-related infections.