【Journal of Materials Chemistry B】An Enzyme-Responsive and Photoactivatable Carbon-Monoxide Releasing Molecule for Bacterial Infection Theranostic
作者：Xianghong Wang, Xin Chen, Lingjie Song, Rongtao Zhou, Shifang Luan*, et al.,
關(guān)鍵字：Enzyme-Responsive,Photoactivatable
論文來源：期刊
具體來源：Journal of Materials Chemistry B
發(fā)表時間：2020年
Abstract：
Infections caused by pathogenic bacteria, especially the drug-resistance bacteria, are posing a devastating threat to public health, which underscores the urgent needs for advanced strategies to effectively prevent and treat the intractable issues. Here we report a feasible and effective theranostic platform based on an enzyme-sensitive and photoactivatable carbon monoxide releasing molecule (CORM-Ac) for successive detection and elimination of bacterial infection. The extracellular bacterial lipase can trigger the excited state intramolecular proton transfer (ESIPT) via elimination of ester group in CORM-Ac, thus providing fluorescence switch for an early warning of infection. Subsequently, the potent bactericidal therapy against the model bacterial strains, Staphylococcus aureus (S. aureus) and notorious methicillin-resistant Staphylococcus aureus (MRSA), were readily realized via photoinduced release of CO. In addition, the CORM-Ac and CORM showed good biocompatibility within a wide range of concentrations. The results of infected animal wound test also demonstrated that CORM-Ac-loaded gauze was effective in indicating the wound infection and accelerating the wound healing via the photoinduced CO release. The simplicity, functional integration, good biocompatibility and broad adaptability make CORM-Ac very attractive for bacterial theranostic applications.