Thermoresponsive Bacterial Cellulose Whisker/Poly(NIPAM- co-BMA) Nanogel Complexes: Synthesis, Characterization, and Biological Evaluation
writer：Lei Wu, Hui Zhou, Hao-Jan Sun,Yanbing Zhao, Xiangliang Yang, Stephen Z. D. Cheng, and
keywords：Bacterial Cellulose
source：期刊
specific source：Biomacromolecules 14(4): 1078-1084.
Issue time：2013年
Dispersions of poly(N-isopropylacrylamide-co -10 butyl methacrylate) (PNB) nanogels are known to exhibit reversible thermosensitive sol ?gel phase behavior and can conseque ntly be used in a wide range of biomedical applications. However, some dissatisfactory mechanical prop-14 erties of PNB nanogels can limit their applications. In this paper, bacterial cellulose (BC) whiskers werefirst prepared by sulfuric acid hydrolysis and then nanosized by high-pressure homogenization for subsequent use in the preparation of BC whisker/PNB nanogel complexes (designated as BC/PNB). The mechanical properties of PNB was successfully enhanced, resulting in good biosafety. The BC/PNB nanogel dispersions exhibited phase transitions from swollen gel to shrunken gel with increasing temperature. In addition, di fferential scanning calorimetry (DSC) data showed that the thermosensitivity of PNB nanogels was retained. Rheological tests also indicated that BC/PNB nanogel complexes had stronger gel strengths when compared with PNB nanogels. The concentrated dispersions showed shear thinning behavior and improved toughness, both of which can play a key role in the medical applications of nanogel complexes. Furthermore, the BC/PNB nanogel complexes were noncytotoxic according to cytotoxicity and hemolysis tests. Concentrated BC/PNB nanogel dispersion displayed gel a forming capacity in situ by catheter injection, which indicates potential for a wide range of medical applications.