[Chem. Commun.] Formal [4+1] annulation of α,α-dialkyl β-oxo amides and dimethylsulfoxonium methylide: a synthetic route to β-hydroxy-γ-lactams
作者：Dingyuan Zhang, Qian Zhang, Ning Zhang,* Rui Zhang, Yongjiu Liang and Dewen Dong*
關(guān)鍵字：lactam, Corey reagent, cyclization
論文來源：期刊
發(fā)表時間：2013年
A facile and efficient one-pot synthesis of β-hydroxy-γ-lactams from α,α-dialkyl β-oxo amides and trimethylsulfoxonium iodide in the presence of sodium hydride via a tandem Corey–Chaykovsky reaction and an intramolecular lactamization process is developed.