80电影天堂网,少妇高潮一区二区三区99,jαpαnesehd熟女熟妇伦,无码人妻精品一区二区蜜桃网站

細(xì)胞形狀作為一個(gè)幾何因素可以影響干細(xì)胞分化，這是近年來(lái)國(guó)際學(xué)術(shù)界一個(gè)涉及生物材料、再生醫(yī)學(xué)和干細(xì)胞命運(yùn)調(diào)控的重要發(fā)現(xiàn)。復(fù)旦大學(xué)高分子科學(xué)系丁建東課題組在此領(lǐng)域也有獨(dú)到研究，相繼發(fā)表多篇文章，如：

Rong Peng, Xiang Yao, and Jiandong Ding*, Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion, Biomaterials, 32, 8048-8057 (2011)

http://www.sciencedirect.com/science/article/pii/S0142961211008064

Xiang Yao, Rong Peng, and Jiandong Ding*, Effects of aspect ratios of stem cells on lineage commitments with and without induction media, Biomaterials, 34(4), 930-939 (2013) 

http://www.sciencedirect.com/science/article/pii/S0142961212012033

Xiang Yao, Rong Peng, and Jiandong Ding*, Cell-material interactions revealed via material techniques of surface patterning, Adv. Mater., 25(37), 5257-5286 (2013) 

http://onlinelibrary.wiley.com/doi/10.1002/adma.201301762/abstract

Bin Cao, Rong Peng, Zhenhua Li, Jiandong Ding*, Effects of spreading areas and aspect ratios of single cells on dedifferentiation of chondrocytes, Biomaterials, 35, 6871-6881 (2014) 

http://www.sciencedirect.com/science/article/pii/S0142961214005201

丁建東課題組近來(lái)還報(bào)道，細(xì)胞器的形狀也可以成為一種影響因素。課題組前期采用微電子技術(shù)制備的模板獲得了高分子材料的微柱陣列。在適當(dāng)?shù)奈㈥嚵谐叨认掠^察到了細(xì)胞核的自我形變，這種細(xì)胞器的形變并不是細(xì)胞整體外形的縮影，具有相對(duì)獨(dú)立性。隨后的深入研究進(jìn)一步發(fā)現(xiàn)，細(xì)胞核變形的半定量程度隨微柱高度呈現(xiàn)類似一級(jí)相變的規(guī)律：這種細(xì)胞核變形即便在經(jīng)過(guò)較長(zhǎng)的干細(xì)胞誘導(dǎo)分化后依然得以保持。在細(xì)胞核的自我形變下，骨髓基質(zhì)干細(xì)胞依然保持了成骨誘導(dǎo)和成脂誘導(dǎo)的潛能，但是分化程度則受到了細(xì)胞核形狀的影響。這種影響與通常人們?cè)跊](méi)有顯著細(xì)胞核變形的平整兩維表面情況下的規(guī)律不一致，揭示了細(xì)胞核有較為強(qiáng)大的調(diào)控功能。

以劉香男博士生為第一作者的13個(gè)印刷頁(yè)的全文于2016年10月4號(hào)在生物材料權(quán)威期刊Biomaterials在線發(fā)表。詳見(jiàn)Subcellular cell geometry on micropillars regulates stem cell differentiation，Xiangnan Liu, Ruili Liu, Bin Cao, Kai Ye, Shiyu Li, Yexin Gu, Zhen Pan, Jiandong Ding*, Biomaterials, 111, 27-39 (2016). 

文章鏈接：http://www.sciencedirect.com/science/article/pii/S0142961216305245