80电影天堂网,少妇高潮一区二区三区99,jαpαnesehd熟女熟妇伦,无码人妻精品一区二区蜜桃网站

搜索：  
Preparation of Drug-Ioaded Porous Poly-L-Iactide Microspheres Using Compressed C02 Antisolvent Process  
Preparation of Drug-Ioaded Porous Poly-L-Iactide Microspheres Using Compressed C02 Antisolvent Process
資料類型： PDF文件
關(guān)鍵詞： compressed  c02  poly-l-iactide  porous  microspheres  pulmonary  drug  
delivery  
資料大小： 105K
所屬學(xué)科： 分子表征
來(lái)源： 第六屆亞歐研討會(huì)上處理和性能增強(qiáng)聚合物會(huì)議文集（2013.6.2-6 武漢）
簡(jiǎn)介：
Byvirtueofexcellentaerodynamicproperties,porousmicrospheres(PMs)havebeenconsideredasaneffectiveinhalabledrugcarrier.Comparedwithtraditionalmethods,supercriticalC02fluidtechnologieshaveshowngreatadvantagesinpreparingPMscl].However,thesizeandporosityoftheresultingPMsusuallycouldnotsimultaneouslymeettherequirementsofpulmonarydrugdelivery.Inourstudy,ammoniumbicarbonate(AB)wasusedasaporogen,poly-L-lactide(PLLA)baseddrug-loadedPMsdevelopedbyanemulsion-combinedC02antisolventprocess.Awater-in-oilemulsion,includingPLLAsolutionindichloromethane(DCM)astheoilphaseandABaqueoussolutionasthewaterphase,wasfirstpreparedbyultrasonication.ThenthecompressedC02at8MPaand300CwasutilizedasanantisolventtoremoveDCMfromthesprayeddroplets,thusprecipitatingPLLAmicrosphereswhichcontainedmicrodropletsofABsolution.PLLAPMswerefinallyobtainedbyvacuumdrying.Takingmethotrexate(MTX)andlysozymeasthesmall-moleculeandbiomacromoleculemodeldrugsrespectively,drug-loadedPLLAPMscouldalsobefabricatedusingthementionedmethod.Theproductsallexhibitedhighlyporousmorphology,withgeometricmeandiameter(Dg)of5-25ym,aerodynamicdiameter(Da)lessthan4.7ym,andporositymorethan70%.Thedrugswereuniformlydispersedinthematrixandtheencapsulationefficienciesofbothdrugswerewithintherangeof50%一80%,withnoburstrelease.FouriertransforminfraredspectroscopyandinvestigationofvitroantitumorefficacyalsorevealedthatboththestructureandfunctionofMTXwerewellmaintainedaftertheloadingprocess;circulardichroismspectrumandenzymaticactivitymeasurementsalsoindicatedthatenvironmental-sensitivebiomacromoleculescouldalsobewellloadedbytheprocess.Theresultsdemonstratethattheprocessusedinthisstudywouldbeapromisingmethodforproducingdrug-loadedPMsforpulmonarydrugdelivery.
作者： A. Chen, C. Zhao, S. Wang, Y. Liu
上傳時(shí)間： 2013-06-28 17:09:05
下載次數(shù)： 1
消耗積分： 2  
立即下載：
好
1人
中
1人
差
1人
友情提示：下載后對(duì)該資源進(jìn)行評(píng)論，即可獎(jiǎng)勵(lì)2分。
報(bào)告錯(cuò)誤：  1.下載無(wú)效　 2. 資料明顯無(wú)價(jià)值　 3. 資料重復(fù)存在

相關(guān)評(píng)論 共有0人發(fā)表評(píng)論 更多評(píng)論
你還沒(méi)有登錄，無(wú)法發(fā)表評(píng)論，請(qǐng)首先 登錄 注冊(cè)
免責(zé)聲明：本站部分資源由網(wǎng)友推薦，來(lái)自互聯(lián)網(wǎng)，版權(quán)屬于原版權(quán)人，如果不慎侵犯到您的權(quán)利，敬請(qǐng)告知，我們會(huì)在第一時(shí)間撤除。本站中各網(wǎng)友的評(píng)論只代表其個(gè)人觀點(diǎn)，不代表本站同意其觀點(diǎn)。