研究方向
主要研究領(lǐng)域?yàn)樯镝t(yī)用高分子材料的研究。針對人類面臨的健康問題，以現(xiàn)代物理及生物學(xué)技術(shù)為指導(dǎo)，主要運(yùn)用自組裝等非傳統(tǒng)的制備技術(shù)，設(shè)計(jì)制備具有特定生物醫(yī)學(xué)應(yīng)用前景的高分子材料，如高分子自組裝薄膜、自組裝微膠囊、微凝膠、水凝膠等高分子生物材料。目前的主要研究課題有：
（1）葡萄糖敏感微凝膠/層層自組裝膜的設(shè)計(jì)、制備及其在胰島素可控釋放與葡萄糖傳感器領(lǐng)域的應(yīng)用。其中葡萄糖敏感微凝膠的研究獲得了國家自然科學(xué)基金的資助。
（2）新型聚合膠態(tài)晶體（生物）傳感器的研究。本項(xiàng)研究獲得了國家自然科學(xué)基金的資助。
（3）溫度敏感微凝膠溶液的實(shí)時(shí)膠凝及其用于可注射三維細(xì)胞支架材料的研究。本項(xiàng)研究獲得了國家科技部國際科技合作項(xiàng)目的資助。
近期代表作：
(1) Chen, M.; Zhang, Y; Jia, Y.; Zhou, L.; Guan, Y.; Zhang, Y.*, Photonic Crystals with a Reversibly Inducible and Erasable Defect State Using External Stimuli. Angew Chem Int Ed 2015, 54(32), 9257-9261.
(2) Chen, M.; Zhou, L.; Guan, Y.; Zhang, Y.*, Polymerized Microgel Colloidal Crystals: Photonic hydrogels with Tunable Bandgap and Fast Response Rate. Angew Chem Int Ed 2013, 52, (38), 9961-9965.
(3) Zhao, Y.; Yuan, Q.; Li, C.; Guan, Y.; Zhang, Y.*, Dynamic layer-by-layer films: a platform for zero-order release, Biomacromolecules 2015, 16(7), 2032-2039.
(4) Zhao, Z.; Gu, J.; Zhao, Y.; Guan, Y.; Zhu, X. X.; Zhang, Y.*, Hydrogel Thin Film with Swelling-Induced Wrinkling Patterns for High-Throughput Generation of Multicellular Spheroids. Biomacromolecules 2014, 15, (9), 3306-3312.
(5) Zhang, X.; Guan, Y.; Zhang, Y.*, Dynamically bonded layer-by-layer films for self-regulated insulin release. Journal of Materials Chemistry 2012, 22, (32), 16299-16305.
(6) Xing, S.; Guan, Y.; Zhang, Y.*, Kinetics of Glucose-Induced Swelling of P(NIPAM-AAPBA) Microgels. Macromolecules 2011, 44, (11), 4479-4486.
(7) Zhang, X.; Guan, Y.; Zhang, Y.*, Ultrathin Hydrogel Films for Rapid Optical Biosensing. Biomacromolecules 2012, 13, (1), 92-97.
(8) Gan, T.; Zhang, Y.*; Guan, Y., In Situ Gelation of P(NIPAM-HEMA) Microgel Dispersion and Its Applications as Injectable 3D Cell Scaffold. Biomacromolecules 2009, 10, (6), 1410-1415.
(9) Wang, D.; Cheng, D.; Guan, Y.; Zhang, Y.*, Thermoreversible Hydrogel for In Situ Generation and Release of HepG2 Spheroids. Biomacromolecules 2011, 12, (3), 578-584.
(10) Gan, T. T.; Guan, Y.; Zhang, Y.*, Thermogelable PNIPAM microgel dispersion as 3D cell scaffold: effect of syneresis. Journal of Materials Chemistry 2010, 20, (28), 5937-5944.
(11) Zhou, L.; Chen, M.; Guan, Y.; Zhang, Y.*, Multiple responsive hydrogel films based on dynamic Schiff base linkages. Polymer Chemistry 2014, 5, 7081-7089.
(12) Tang, Z.; Guan, Y.; Zhang, Y.*, Contraction-type glucose-sensitive microgel functionalized with a 2-substituted phenylboronic acid ligand. Polymer Chemistry 2014, 5, (5), 1782-1790.
