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Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds  
Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds
資料類型: PDF文件
關(guān)鍵詞: biodegradable  plla  tissue  scaffolds  
資料大?。?/td> 72K
所屬學科: 分子表征
來源: 第六屆亞歐研討會上處理和性能增強聚合物會議文集(2013.6.2-6 武漢)
簡介:
Inseveralbranchesofthemedicalfield,fromcardiologyorthopaedicstotissueengineering,therehasbeenanincreasingtrendintheuseofbiodegradablematerialsinplaceoftraditional,biostablematerials,suchasmetals,ceramicsandsyntheticpolymers.Biodegradablepolymersandtheircompositesareprominentintheseareasandareofgreatinterestforresearchbecausethereismuchroomforimprovement.Thispaperwillfocusontheapplicationofpolymerblendsandcompositesinbioabsorbablestentsandtissuescaffolds.PLLAisveryprominentinthefieldofbioabsorbablestentsbutitsuffersfrombrittlenesswhichmustbemitigated.OnemethodofdoingthisistoblendPLLAwithrubberypolymerstocreateductileblendswhichstrikeabalancebetweenductility,strength,modulusanddegradationcharacteristics.Thispaperdiscussesthedevelopmentoftheirmechanicalcharacteristics,fromYoung‘smodulustocreep,whichoccursduringdegradation.PLLAisalsoacommonmaterialunderinvestigationfortissuescaffolds.Alargeproportionofworkinthisareafocusesonelectrospinningtocreatetissuescaffoldsbutthisrequirestheuseoforganicsolvents.AprocessforproducingscaffoldswithouttheuseoforganicsolventshasbeendevelopedattheCentreforAdvancedCompositeMaterials,TheUniversityofAuckland.Theprocessinvolvesdrawingofanextrudedpolymercompositefilamenttofibrilisethedispersedphase.Afterproducinganetworkofmicro-/nano-fibrilsthroughacommonmanufacturingtechnique,thematrixisremovedviadissolutioninwater,leavinga3-Dfibrillar,nanoporousnetwork.Thisnetworkcanbeusedasatissuescaffoldwiththeadvantageoverelectrospunnetworksofhavingnoresidualorganicsolventcontent.Thispaperdescribestheprocessofscaffoldmanufacturingwithsomeresultsofin-vitrocellculture.
作者: D. Bhattacharyya* , L. Kimble, S. Lin
上傳時間: 2013-06-21 11:39:18
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