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Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds  
Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds
資料類型： PDF文件
關(guān)鍵詞： biodegradable  plla  tissue  scaffolds  
資料大?。?/td> 72K
所屬學(xué)科： 分子表征
來源： 第六屆亞歐研討會(huì)上處理和性能增強(qiáng)聚合物會(huì)議文集（2013.6.2-6 武漢）
簡介：
Inseveralbranchesofthemedicalfield,fromcardiologyorthopaedicstotissueengineering,therehasbeenanincreasingtrendintheuseofbiodegradablematerialsinplaceoftraditional,biostablematerials,suchasmetals,ceramicsandsyntheticpolymers.Biodegradablepolymersandtheircompositesareprominentintheseareasandareofgreatinterestforresearchbecausethereismuchroomforimprovement.Thispaperwillfocusontheapplicationofpolymerblendsandcompositesinbioabsorbablestentsandtissuescaffolds.PLLAisveryprominentinthefieldofbioabsorbablestentsbutitsuffersfrombrittlenesswhichmustbemitigated.OnemethodofdoingthisistoblendPLLAwithrubberypolymerstocreateductileblendswhichstrikeabalancebetweenductility,strength,modulusanddegradationcharacteristics.Thispaperdiscussesthedevelopmentoftheirmechanicalcharacteristics,fromYoung‘smodulustocreep,whichoccursduringdegradation.PLLAisalsoacommonmaterialunderinvestigationfortissuescaffolds.Alargeproportionofworkinthisareafocusesonelectrospinningtocreatetissuescaffoldsbutthisrequirestheuseoforganicsolvents.AprocessforproducingscaffoldswithouttheuseoforganicsolventshasbeendevelopedattheCentreforAdvancedCompositeMaterials,TheUniversityofAuckland.Theprocessinvolvesdrawingofanextrudedpolymercompositefilamenttofibrilisethedispersedphase.Afterproducinganetworkofmicro-/nano-fibrilsthroughacommonmanufacturingtechnique,thematrixisremovedviadissolutioninwater,leavinga3-Dfibrillar,nanoporousnetwork.Thisnetworkcanbeusedasatissuescaffoldwiththeadvantageoverelectrospunnetworksofhavingnoresidualorganicsolventcontent.Thispaperdescribestheprocessofscaffoldmanufacturingwithsomeresultsofin-vitrocellculture.
作者： D. Bhattacharyya* , L. Kimble, S. Lin
上傳時(shí)間： 2013-06-21 11:39:18
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